Ontology highlight
ABSTRACT:
SUBMITTER: Muftuoglu M
PROVIDER: S-EPMC2666579 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Muftuoglu Meltem M de Souza-Pinto Nadja C NC Dogan Arin A Aamann Maria M Stevnsner Tinna T Rybanska Ivana I Kirkali Güldal G Dizdaroglu Miral M Bohr Vilhelm A VA
The Journal of biological chemistry 20090129 14
Cockayne syndrome (CS) is a premature aging condition characterized by sensitivity to UV radiation. However, this phenotype does not explain the progressive neurodegeneration in CS patients. It could be due to the hypersensitivity of CSB-deficient cells to oxidative stress. So far most studies on the role of CSB in repair of oxidatively induced DNA lesions have focused on 7,8-dihydro-8-oxoguanine. This study examines the role of CSB in the repair of formamidopyrimidines 2,6-diamino-4-hydroxy-5-f ...[more]