Ontology highlight
ABSTRACT:
SUBMITTER: Mani V
PROVIDER: S-EPMC2666939 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Mani Vigneshwaran V Chikkaveeraiah Bhaskara V BV Patel Vyomesh V Gutkind J Silvio JS Rusling James F JF
ACS nano 20090301 3
A densely packed gold nanoparticle platform combined with a multiple-enzyme labeled detection antibody-magnetic bead bioconjugate was used as the basis for an ultrasensitive electrochemical immunosensor to detect cancer biomarkers in serum. Sensitivity was greatly amplified by synthesizing magnetic bioconjugates particles containing 7500 horseradish peroxidase (HRP) labels along with detection antibodies (Ab2) attached to activated carboxyl groups on 1 microm diameter magnetic beads. These senso ...[more]