Mining the ovarian cancer ascites proteome for potential ovarian cancer biomarkers.
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ABSTRACT:
SUBMITTER: Kuk C
PROVIDER: S-EPMC2667349 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Mining the ovarian cancer ascites proteome for potential ovarian cancer biomarkers.
Kuk Cynthia C Kulasingam Vathany V Gunawardana C Geeth CG Smith Chris R CR Batruch Ihor I Diamandis Eleftherios P EP
Molecular & cellular proteomics : MCP 20081201 4
Current ovarian cancer biomarkers are inadequate because of their relatively low diagnostic sensitivity and specificity. There is a need to discover and validate novel ovarian cancer biomarkers that are suitable for early diagnosis, monitoring, and prediction of therapeutic response. We performed an in-depth proteomics analysis of ovarian cancer ascites fluid. Size exclusion chromatography and ultrafiltration were used to remove high abundance proteins with molecular mass >/=30 kDa. After trypsi ...[more]
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