Ontology highlight
ABSTRACT:
SUBMITTER: O'Connor T
PROVIDER: S-EPMC2667382 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
O'Connor Tracy T Sadleir Katherine R KR Maus Erika E Velliquette Rodney A RA Zhao Jie J Cole Sarah L SL Eimer William A WA Hitt Brian B Bembinster Leslie A LA Lammich Sven S Lichtenthaler Stefan F SF Hébert Sébastien S SS De Strooper Bart B Haass Christian C Bennett David A DA Vassar Robert R
Neuron 20081201 6
beta-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for beta-amyloid (Abeta) production, is elevated in Alzheimer's disease (AD). Here, we show that energy deprivation induces phosphorylation of the translation initiation factor eIF2alpha (eIF2alpha-P), which increases the translation of BACE1. Salubrinal, an inhibitor of eIF2alpha-P phosphatase PP1c, directly increases BACE1 and elevates Abeta production in primary neurons. Preventing eIF2alpha phosphorylation by transfection with ...[more]