Ontology highlight
ABSTRACT:
SUBMITTER: Lu PD
PROVIDER: S-EPMC1271668 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Lu Phoebe D PD Jousse Céline C Marciniak Stefan J SJ Zhang Yuhong Y Novoa Isabel I Scheuner Donalyn D Kaufman Randal J RJ Ron David D Harding Heather P HP
The EMBO journal 20040108 1
Transient phosphorylation of the alpha-subunit of translation initiation factor 2 (eIF2alpha) represses translation and activates select gene expression under diverse stressful conditions. Defects in the eIF2alpha phosphorylation-dependent integrated stress response impair resistance to accumulation of malfolded proteins in the endoplasmic reticulum (ER stress), to oxidative stress and to nutrient deprivations. To study the hypothesized protective role of eIF2alpha phosphorylation in isolation o ...[more]