Ontology highlight
ABSTRACT:
SUBMITTER: Wang CC
PROVIDER: S-EPMC2667781 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Wang Chih-Chieh CC Houng Hsiang-Chee HC Chen Chun-Liang CL Wang Pei-Ju PJ Kuo Chih-Feng CF Lin Yee-Shin YS Wu Jiunn-Jong JJ Lin Ming T MT Liu Ching-Chuan CC Huang Wenya W Chuang Woei-Jer WJ
The Journal of biological chemistry 20090223 16
Streptococcal pyrogenic exotoxin B (SPE B) is a cysteine protease expressed by Streptococcus pyogenes. The D9N, G163S, G163S/A172S, and G239D mutant proteins were expressed to study the effect of the allelic variants on their protease activity. In contrast to other mutants, the G239D mutant was approximately 12-fold less active. The Gly-239 residue is located within the C-terminal S230-G239 region, which cannot be observed in the x-ray structure. The three-dimensional structure and backbone dyna ...[more]