Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka T
PROVIDER: S-EPMC2667971 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
American journal of human genetics 20090319 4
The B vitamins are components of one-carbon metabolism (OCM) that contribute to DNA synthesis and methylation. Homocysteine, a by-product of OCM, has been associated with coronary heart disease, stroke and neurological disease. To investigate genetic factors that affect circulating vitamin B6, vitamin B12, folate and homocysteine, a genome-wide association analysis was conducted in the InCHIANTI (N = 1175), SardiNIA (N = 1115), and BLSA (N = 640) studies. The top loci were replicated in an indep ...[more]