Ontology highlight
ABSTRACT:
SUBMITTER: Avenarius MR
PROVIDER: S-EPMC2667975 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Avenarius Matthew R MR Hildebrand Michael S MS Zhang Yuzhou Y Meyer Nicole C NC Smith Luke L H LL Kahrizi Kimia K Najmabadi Hossein H Smith Richard J H RJ
American journal of human genetics 20090402 4
Male infertility, a common barrier that prevents successful conception, is a reproductive difficulty affecting 15% of couples. Heritable forms of nonsyndromic male infertility can arise from single-gene defects as well as chromosomal abnormalities. Although no CATSPER gene has been identified as causative for human male infertility, male mice deficient for members of the CatSper gene family are infertile. In this study, we used routine semen analysis to identify two consanguineous Iranian famili ...[more]