Ontology highlight
ABSTRACT:
SUBMITTER: Webster JA
PROVIDER: S-EPMC2667989 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
American journal of human genetics 20090401 4
We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. We have now analyzed additional samples with a confirmed pathologic diagnosis of late-onset Alzheimer disease (LOAD; final n = 188 controls, 176 cases). Nine percent of the cortical transcripts that we analyzed had expression profiles correlated with their genotypes in the combined cohort, and approximately 5% of transcripts had SNP-transcript relat ...[more]