Changes in brain gene expression shared by scrapie and Alzheimer disease.
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ABSTRACT:
SUBMITTER: Duguid JR
PROVIDER: S-EPMC298037 | biostudies-other | 1989 Sep
REPOSITORIES: biostudies-other
Publications
Changes in brain gene expression shared by scrapie and Alzheimer disease.
Duguid J R JR Bohmont C W CW Liu N G NG Tourtellotte W W WW
Proceedings of the National Academy of Sciences of the United States of America 19890901 18
We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-m ...[more]
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