Ontology highlight
ABSTRACT:
SUBMITTER: Xu P
PROVIDER: S-EPMC2668214 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Xu Ping P Duong Duc M DM Seyfried Nicholas T NT Cheng Dongmei D Xie Yang Y Robert Jessica J Rush John J Hochstrasser Mark M Finley Daniel D Peng Junmin J
Cell 20090401 1
All seven lysine residues in ubiquitin contribute to the synthesis of polyubiquitin chains on protein substrates. Whereas K48-linked chains are well established as mediators of proteasomal degradation, and K63-linked chains act in nonproteolytic events, the roles of unconventional polyubiquitin chains linked through K6, K11, K27, K29, or K33 are not well understood. Here, we report that the unconventional linkages are abundant in vivo and that all non-K63 linkages may target proteins for degrada ...[more]