Ontology highlight
ABSTRACT:
SUBMITTER: Meyer HJ
PROVIDER: S-EPMC4028144 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Meyer Hermann-Josef HJ Rape Michael M
Cell 20140501 4
Posttranslational modification of cell-cycle regulators with ubiquitin chains is essential for eukaryotic cell division. Such chains can be connected through seven lysine residues or the amino terminus of ubiquitin, thereby allowing the assembly of eight homogenous and multiple mixed or branched conjugates. Although functions of homogenous chain types have been described, physiological roles of branched structures are unknown. Here, we report that the anaphase-promoting complex (APC/C) efficient ...[more]