Ontology highlight
ABSTRACT:
SUBMITTER: Caporale M
PROVIDER: S-EPMC2668452 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Caporale Marco M Arnaud Frederick F Mura Manuela M Golder Matthew M Murgia Claudio C Palmarini Massimo M
Journal of virology 20090225 9
Retroviruses use different strategies to regulate transcription and translation and exploit the cellular machinery involved in these processes. This study shows that the signal peptide of the envelope glycoprotein (Env) of Jaagsiekte sheep retrovirus (JSRV) plays a major role in posttranscriptional viral gene expression. Expression of the JSRV Env in trans increases viral particle production by mechanisms dependent on (i) its leader sequence, (ii) an intact signal peptide cleavage site, (iii) a ...[more]