Ontology highlight
ABSTRACT:
SUBMITTER: van Leuken R
PROVIDER: S-EPMC2668763 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
van Leuken Renske R Clijsters Linda L van Zon Wouter W Lim Dan D Yao XueBiao X Wolthuis Rob M F RM Yaffe Michael B MB Medema René H RH van Vugt Marcel A T M MA
PloS one 20090423 4
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-betaTrCP. Here, we show that Plk1 is also required for the timely destruction of its activator Aurora A in late anaphase. It has been shown that Aurora A destruction is controlled by the auxiliary subunit Cdh1 of the Anaphase-Promoting Complex/Cyclosome (APC/C). Remarkably, we found that Plk1-depletion ...[more]