Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4496220 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Li Jingjing J Hong Myung Jin MJ Chow Jeremy P H JP Man Wing Yu WY Mak Joyce P Y JP Ma Hoi Tang HT Poon Randy Y C RY
Oncotarget 20150401 11
Mitosis is choreographed by a number of protein kinases including polo-like kinases and Aurora kinases. As these kinases are frequently dysregulated in cancers, small-molecule inhibitors have been developed for targeted anticancer therapies. Given that PLK1 and Aurora kinases possess both unique functions as well as co-regulate multiple mitotic events, whether pharmacological inhibition of these kinases together can enhance mitotic catastrophe remains an outstanding issue to be determined. Using ...[more]