The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell death.
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ABSTRACT:
SUBMITTER: Cunningham LL
PROVIDER: S-EPMC2668867 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
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The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell death.
Brain research 20060329 1
Sensory hair cells of the inner ear are susceptible to death from a variety of stresses including aging, noise trauma, genetic disorders, and exposure to certain therapeutic drugs. Ototoxic drugs include the aminoglycoside antibiotics and the antineoplastic agent cisplatin. This is a short technical report describing the dissection and culture of the adult mouse utricle. This in vitro preparation allows for detailed studies of ototoxic-drug-induced hair cell death in an adult mammalian system. I ...[more]
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