Ontology highlight
ABSTRACT:
SUBMITTER: Cordle J
PROVIDER: S-EPMC2669539 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Cordle Jemima J Johnson Steven S Tay Joyce Zi Yan JZ Roversi Pietro P Wilkin Marian B MB de Madrid Beatriz Hernández BH Shimizu Hideyuki H Jensen Sacha S Whiteman Pat P Jin Boquan B Redfield Christina C Baron Martin M Lea Susan M SM Handford Penny A PA
Nature structural & molecular biology 20080727 8
The Notch receptor and its ligands are key components in a core metazoan signaling pathway that regulates the spatial patterning, timing and outcome of many cell-fate decisions. Ligands contain a disulfide-rich Delta/Serrate/LAG-2 (DSL) domain required for Notch trans-activation or cis-inhibition. Here we report the X-ray structure of a receptor binding region of a Notch ligand, the DSL-EGF3 domains of human Jagged-1 (J-1(DSL-EGF3)). The structure reveals a highly conserved face of the DSL domai ...[more]