Ontology highlight
ABSTRACT:
SUBMITTER: Fleming RJ
PROVIDER: S-EPMC3631976 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Fleming Robert J RJ Hori Kazuya K Sen Anindya A Filloramo Gina V GV Langer Jillian M JM Obar Robert A RA Artavanis-Tsakonas Spyros S Maharaj-Best Ayiti C AC
Development (Cambridge, England) 20130501 9
Cell-to-cell communication via the Notch pathway is mediated between the membrane-bound Notch receptor and either of its canonical membrane-bound ligands Delta or Serrate. Notch ligands mediate receptor transactivation between cells and also mediate receptor cis-inhibition when Notch and ligand are co-expressed on the same cell. We demonstrate in Drosophila that removal of any of the EGF-like repeats (ELRs) 4, 5 or 6 results in a Serrate molecule capable of transactivating Notch but exhibiting l ...[more]