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Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs.

ABSTRACT: The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts-one originally identified from a catalyst screen (5) and its enantiomer (ent-5)-for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA.

SUBMITTER: Lewis CA

PROVIDER: S-EPMC2669672 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs.

Lewis Chad A CA Merkel Janie J Miller Scott J SJ

Bioorganic & medicinal chemistry letters 20080909 22

The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts-one originally identified from a catalyst screen (5) and its enantiomer (ent-5)-for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA. ...[more]

PMID: 18819795

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