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Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs.

ABSTRACT: The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5' position of the DNA binding subunit, are described.

SUBMITTER: Robertson WM

PROVIDER: S-EPMC2867475 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs.

Robertson William M WM Kastrinsky David B DB Hwang Inkyu I Boger Dale L DL

Bioorganic & medicinal chemistry letters 20100325 9

The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5' position of the DNA binding subunit, are described. ...[more]

PMID: 20381346

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