Ontology highlight
ABSTRACT:
SUBMITTER: Gaitanos TN
PROVIDER: S-EPMC2669960 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Gaitanos Thomas N TN Santamaria Anna A Jeyaprakash A Arockia AA Wang Bin B Conti Elena E Nigg Erich A EA
The EMBO journal 20090409 10
Ska1 and Ska2 form a complex at the kinetochore-microtubule (KT-MT) interface and are required for timely progression from metaphase to anaphase. Here, we use mass spectrometry to search for additional components of the Ska complex. We identify C13Orf3 (now termed Ska3) as a novel member of this complex and map the interaction domains among the three known components. Ska3 displays similar characteristics as Ska1 and Ska2: it localizes to the spindle and KT throughout mitosis and its depletion m ...[more]