Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function.
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ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC2670242 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function.
Wang Dairong D Patel Vickas V VV Ricciotti Emanuela E Zhou Rong R Levin Mark D MD Gao Ehre E Yu Zhou Z Ferrari Victor A VA Lu Min Min MM Xu Junwang J Zhang Hualei H Hui Yiqun Y Cheng Yan Y Petrenko Nataliya N Yu Ying Y FitzGerald Garret A GA
Proceedings of the National Academy of Sciences of the United States of America 20090417 18
Nonsteroidal anti-inflammatory drugs selective for inhibition of COX-2 increase heart failure and elevate blood pressure. The COX-2 gene was floxed and crossed into merCremer mice under the alpha-myosin heavy-chain promoter. Tamoxifen induced selective deletion of COX-2 in cardiomyocytes depressed cardiac output, and resulted in weight loss, diminished exercise tolerance, and enhanced susceptibility to induced arrhythmogenesis. The cardiac dysfunction subsequent to pressure overload recovered pr ...[more]
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