Ontology highlight
ABSTRACT:
SUBMITTER: Finegan KG
PROVIDER: S-EPMC2670276 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Finegan K G KG Wang X X Lee E-J EJ Robinson A C AC Tournier C C
Cell death and differentiation 20090116 5
The extracellular signal-regulated protein kinase 5 (ERK5) is a mitogen-activated protein kinase that phosphorylates and regulates various transcription factors in response to growth factors and extracellular stresses. To address its biological function during the development of the peripheral nervous system (PNS), we have engineered a novel model of sympathetic neurons in which the erk5 gene can be deleted in vitro. Our data provide for the first time genetic evidence that ERK5 is required to m ...[more]