Ontology highlight
ABSTRACT:
SUBMITTER: Veldkamp CT
PROVIDER: S-EPMC2670582 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Veldkamp Christopher T CT Seibert Christoph C Peterson Francis C FC Sakmar Thomas P TP Volkman Brian F BF
Journal of molecular biology 20060511 5
Tyrosine sulfation of the chemokine receptor CXCR4 enhances its interaction with the chemokine SDF-1alpha. Given similar post-translational modification of other receptors, including CCR5, CX3CR1 and CCR2b, tyrosine sulfation may be of universal importance in chemokine signaling. N-terminal domains from seven transmembrane chemokine receptors have been employed for structural studies of chemokine-receptor interactions, but never in the context of proper post-translational modifications known to ...[more]