Ontology highlight
ABSTRACT:
SUBMITTER: Misra R
PROVIDER: S-EPMC2671569 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Misra Rajeev R Bavro Vassiliy N VN
Biochimica et biophysica acta 20090313 5
Multidrug efflux (MDR) pumps remove a variety of compounds from the cell into the external environment. There are five different classes of MDR pumps in bacteria, and quite often a single bacterial species expresses multiple classes of pumps. Although under normal circumstances MDR pumps confer low-level intrinsic resistance to drugs, the presence of drugs and mutations in regulatory genes lead to high level expression of MDR pumps that can pose problems with therapeutic treatments. This review ...[more]