Ontology highlight
ABSTRACT:
SUBMITTER: Tsutsumi K
PROVIDER: S-EPMC6447562 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nature communications 20190403 1
In Pseudomonas aeruginosa, MexAB-OprM plays a central role in multidrug resistance by ejecting various drug compounds, which is one of the causes of serious nosocomial infections. Although the structures of the components of MexAB-OprM have been solved individually by X-ray crystallography, no structural information for fully assembled pumps from P. aeruginosa were previously available. In this study, we present the structure of wild-type MexAB-OprM in the presence or absence of drugs at near-at ...[more]