Male-pattern baldness susceptibility locus at 20p11.
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ABSTRACT:
SUBMITTER: Richards JB
PROVIDER: S-EPMC2672151 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Male-pattern baldness susceptibility locus at 20p11.
Richards J Brent JB Yuan Xin X Geller Frank F Waterworth Dawn D Bataille Veronique V Glass Daniel D Song Kijoung K Waeber Gerard G Vollenweider Peter P Aben Katja K H KK Kiemeney Lambertus A LA Walters Bragi B Soranzo Nicole N Thorsteinsdottir Unnur U Kong Augustine A Rafnar Thorunn T Deloukas Panos P Sulem Patrick P Stefansson Hreinn H Stefansson Kari K Spector Tim D TD Mooser Vincent V
Nature genetics 20081012 11
We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)). ...[more]
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