Ontology highlight
ABSTRACT:
SUBMITTER: Palanker L
PROVIDER: S-EPMC2673486 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Cell metabolism 20090301 3
Drosophila HNF4 (dHNF4) is the single ancestral ortholog of a highly conserved subfamily of nuclear receptors that includes two mammalian receptors, HNFalpha and HNFgamma, and 269 members in C. elegans. We show here that dHNF4 null mutant larvae are sensitive to starvation. Starved mutant larvae consume glycogen normally but retain lipids in their midgut and fat body and have increased levels of long-chain fatty acids, suggesting that they are unable to efficiently mobilize stored fat for energy ...[more]