Ontology highlight
ABSTRACT:
SUBMITTER: Hatziapostolou M
PROVIDER: S-EPMC3251960 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Cell 20111201 6
Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24, and miR-629. Moreover, we show that, once this circuit is activated, it maintains suppression of HNF4α and sustains oncogenesis. Systemic administration of miR-124, which modulates inflammatory signaling, prevents an ...[more]