Antibody polyspecificity and neutralization of HIV-1: a hypothesis.
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ABSTRACT:
SUBMITTER: Haynes BF
PROVIDER: S-EPMC2673565 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
Antibody polyspecificity and neutralization of HIV-1: a hypothesis.
Haynes Barton F BF Moody M Anthony MA Verkoczy Laurent L Kelsoe Garnett G Alam S Munir SM
Human antibodies 20050101 3-4
HIV-1 has evolved many ways to evade protective host immune responses, thus creating a number of problems for HIV vaccine developers. In particular, durable, broadly specific neutralizing antibodies to HIV-1 have proved difficult to induce with current HIV-1 vaccine candidates. The recent observation that some broadly neutralizing anti-HIV-1 envelope monoclonal antibodies have polyspecific reactivities to host antigens have raised the hypothesis that one reason antibodies against some of the con ...[more]
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