Ontology highlight
ABSTRACT:
SUBMITTER: van Schooten J
PROVIDER: S-EPMC6260891 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
van Schooten Jelle J van Gils Marit J MJ
Retrovirology 20181126 1
Despite enormous efforts no HIV-1 vaccine has been developed that elicits broadly neutralizing antibodies (bNAbs) to protect against infection to date. The high antigenic diversity and dense N-linked glycan armor, which covers nearly the entire HIV-1 envelope protein (Env), are major roadblocks for the development of bNAbs by vaccination. In addition, the naive human antibody repertoire features a low frequency of exceptionally long heavy chain complementary determining regions (CDRH3s), which i ...[more]