Ontology highlight
ABSTRACT:
SUBMITTER: Rauch M
PROVIDER: S-EPMC2673681 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Rauch Melanie M Tussiwand Roxane R Bosco Nabil N Rolink Antonius G AG
PloS one 20090506 5
Defects in the expression of either BAFF (B cell activating factor) or BAFF-R impairs B cell development beyond the immature, transitional type-1 stage and thus, prevents the formation of follicular and marginal zone B cells, whereas B-1 B cells remain unaffected. The expression of BAFF-R on all mature B cells might suggest a role for BAFF-R signaling also for their in vivo maintenance. Here, we show that, 14 days following a single injection of an anti-BAFF-R mAb that prevents BAFF binding, bot ...[more]