Ontology highlight
ABSTRACT:
SUBMITTER: Papeta N
PROVIDER: S-EPMC2673856 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Papeta Natalia N Chan Ka-Tak KT Prakash Sindhuri S Martino Jeremiah J Kiryluk Krzysztof K Ballard David D Bruggeman Leslie A LA Frankel Rachelle R Zheng Zongyu Z Klotman Paul E PE Zhao Hongyu H D'Agati Vivette D VD Lifton Richard P RP Gharavi Ali G AG
The Journal of clinical investigation 20090420 5
Multiple studies have linked podocyte gene variants to diverse sporadic nephropathies, including HIV-1-associated nephropathy (HIVAN). We previously used linkage analysis to identify a major HIVAN susceptibility locus in mouse, HIVAN1. We performed expression quantitative trait locus (eQTL) analysis of podocyte genes in HIV-1 transgenic mice to gain further insight into genetic susceptibility to HIVAN. In 2 independent crosses, we found that transcript levels of the podocyte gene nephrosis 2 hom ...[more]