Ontology highlight
ABSTRACT:
SUBMITTER: Kammoun HL
PROVIDER: S-EPMC2673873 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Kammoun Hélène L HL Chabanon Hervé H Hainault Isabelle I Luquet Serge S Magnan Christophe C Koike Tatsuro T Ferré Pascal P Foufelle Fabienne F
The Journal of clinical investigation 20090413 5
Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active lipogenesis. Hepatic lipogenesis depends on the insulin-induced activation of the transcription factor SREBP-1c. Despite prevailing insulin resistance, SREBP-1c is activated in the livers of genetically and diet-induced obese rodents. Recent studies have reported the presence of an ER stress response in the livers of obese ob/ob mice. To assess whether ER stress promotes SREBP-1c activation and thus co ...[more]