Ontology highlight
ABSTRACT:
SUBMITTER: Wei Q
PROVIDER: S-EPMC6113258 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Wei Qin Q Zhou Baoyong B Yang Gangyi G Hu Wenjing W Zhang Lili L Liu Rui R Li Minyan M Wang Kuan K Gu Harvest F HF Guan Youfei Y Zhu Zhiming Z Zheng Hongting H Peng Jun J Li Ling L
Cell death & disease 20180828 9
JAZF zinc finger 1 (JAZF1) is involved in glucose and lipid metabolisms. However, its role in aging- and nutrient-related hepatic steatosis is unclear. In the current study, we demonstrated that JAZF1 expression was markedly down-regulated in obesity-associated mice and nonalcoholic fatty liver disease (NAFLD) patients. During aging, JAZF1 expression was gradually down-regulated in both C57BL/6 J and JAZF1-Tg mice. In JAZF1-Tg mice, body fat content and hepatosteatosis were protected from HFD-in ...[more]