Ontology highlight
ABSTRACT:
SUBMITTER: Zeng S
PROVIDER: S-EPMC2675667 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Zeng Sicong S Xiang Tao T Pandita Tej K TK Gonzalez-Suarez Ignacio I Gonzalo Susana S Harris Curtis C CC Yang Qin Q
Nature cell biology 20090412 5
Telomerase-negative cancer cells maintain their telomeres through the alternative lengthening of telomeres (ALT) pathway. Although a growing body of evidence demonstrates that the ALT mechanism is a post-replicative telomere recombination process, molecular details of this pathway are largely unknown. Here we demonstrate that MUS81, a DNA structure specific recombination endonuclease, has a key role in the maintenance of telomeres in human ALT cells. We find that MUS81 specifically localizes to ...[more]