Ontology highlight
ABSTRACT:
SUBMITTER: Villanueva A
PROVIDER: S-EPMC2678688 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Villanueva Augusto A Chiang Derek Y DY Newell Pippa P Peix Judit J Thung Swan S Alsinet Clara C Tovar Victoria V Roayaie Sasan S Minguez Beatriz B Sole Manel M Battiston Carlo C Van Laarhoven Stijn S Fiel Maria I MI Di Feo Analisa A Hoshida Yujin Y Yea Steven S Toffanin Sara S Ramos Alex A Martignetti John A JA Mazzaferro Vincenzo V Bruix Jordi J Waxman Samuel S Schwartz Myron M Meyerson Matthew M Friedman Scott L SL Llovet Josep M JM
Gastroenterology 20080820 6
<h4>Background & aims</h4>The advent of targeted therapies in hepatocellular carcinoma (HCC) has underscored the importance of pathway characterization to identify novel molecular targets for treatment. We evaluated mTOR signaling in human HCC, as well as the antitumoral effect of a dual-level blockade of the mTOR pathway.<h4>Methods</h4>The mTOR pathway was assessed using integrated data from mutation analysis (direct sequencing), DNA copy number changes (SNP-array), messenger RNA levels (quant ...[more]