The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism.
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ABSTRACT:
SUBMITTER: Tian LY
PROVIDER: S-EPMC9916527 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Publications
The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism.
Tian Ling-Yu LY Smit Daniel J DJ Jücker Manfred M
International journal of molecular sciences 20230131 3
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains unclearly described in HCC. The dysregulation of the PI3K/AKT/mTOR signaling pathway is common in HCC and is, therefore, a topic of further research and the concern of developing a novel target for liver cancer therapy. In this review, we illustrate mechanisms by which this signaling network is accountable for regulating ...[more]
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