Ontology highlight
ABSTRACT:
SUBMITTER: Chae SC
PROVIDER: S-EPMC2679282 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Chae Soo Cheon SC Shim Seung Cheol SC Chung Hun Taeg HT
Experimental & molecular medicine 20090101 1
TBX21 (T-bet) is a member of the T-box family of transcriptional factors that contain a conserved DNA binding domain. TBX21 is a critical regulator of the commitment to the Th1 lineage and IFN-gamma production. Th1 and Th2 cells cross-regulate the differentiation of each other, and in this way TBX21 could be an attractive candidate gene for treating autoimmune disease such as rheumatoid arthritis (RA). In present study, we analyzed the genotypic frequencies of six polymorphisms of the TBX21 gene ...[more]