Dataset Information

Association of BLK and BANK1 Polymorphisms and Interactions With Rheumatoid Arthritis in a Latin-American Population.

ABSTRACT: Introduction:BLK has been identified as a risk factor to rheumatoid arthritis (RA) primarily in Asian or European-derived populations. However, this finding has not been evaluated in other populations such as Latin-Americans, except for Colombians. On the other hand, BANK1 single nucleotide variants (SNVs) have been scarcely studied in RA patients. Objective:The aim of this study was to determine whether the BLK rs2736340T/C, rs13277113A/G, and BANK1 rs10516487G/A (R61H) and rs3733197G/A (A383T) polymorphisms are risk factors to RA in a sample of patients from Central Mexico. Materials and Methods:We studied 957 women; 487 controls and 470 patients with RA by means of a TaqMan® SNP genotyping assay with fluorescent probes for the BLK rs13277113A/G, rs2736340T/C and BANK1 10516487G/A (R61H) and rs3733197G/A (A383T) variants. Result:The BLK rs2736340T/C and rs13277113A/G variants were associated with risk for RA: C vs T; OR 1.39, p = 0.001, and G vs A; OR 1.37, p = 0.004, respectively. In addition, there was also an association between BANK1 R61H and RA: A vs G; OR 1.49, p = 0.003, but no with BANK1 A383T. We also identified an interaction significant between genotypes of BLK rs2736340T/C-BANK1 rs10516487G/A and RA: OR 1.65, p = 0.0001. Conclusions:Our data suggest that both BLK and BANK1 confer susceptibility to RA in Mexican patients. The individual association of BANK1 rs1054857G/A with RA had not been previously reported in a particular population (except for pooled patients from several countries), therefore, our study presents the first evidence of association between this BANK1 variant and RA.

SUBMITTER: Ramirez-Bello J

PROVIDER: S-EPMC7045059 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Association of <i>BLK</i> and <i>BANK1</i> Polymorphisms and Interactions With Rheumatoid Arthritis in a Latin-American Population.

Ramírez-Bello Julian J Fragoso José M JM Alemán-Ávila Isidro I Jiménez-Morales Silvia S Campos-Parra Alma D AD Barbosa-Cobos Rosa Elda RE Moreno José J

Frontiers in genetics 20200220

<h4>Introduction</h4><i>BLK</i> has been identified as a risk factor to rheumatoid arthritis (RA) primarily in Asian or European-derived populations. However, this finding has not been evaluated in other populations such as Latin-Americans, except for Colombians. On the other hand, <i>BANK1</i> single nucleotide variants (SNVs) have been scarcely studied in RA patients.<h4>Objective</h4>The aim of this study was to determine whether the BLK rs2736340T/C, rs13277113A/G, and BANK1 rs10516487G/A (R ...[more]

PMID: 32153635

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Dataset Information

Association of BLK and BANK1 Polymorphisms and Interactions With Rheumatoid Arthritis in a Latin-American Population.

Publications

Association of <i>BLK</i> and <i>BANK1</i> Polymorphisms and Interactions With Rheumatoid Arthritis in a Latin-American Population.

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