Ontology highlight
ABSTRACT:
SUBMITTER: Kim TY
PROVIDER: S-EPMC2679347 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Kim Tai Young TY Kim In Sook IS Jong Hyun Soon HS Lee Jung Weon JW Kim Tae You TY Jung Mira M Bang Yung Jue YJ
Experimental & molecular medicine 20081201 6
We previously reported that trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, induced DLC-1 mRNA expression and accumulated acetylated histones H3 and H4 associated with the DLC-1 promoter in DLC-1 non-expressing gastric cancer cells. In this study, we demonstrated the molecular mechanisms by which TSA induced the DLC-1 gene expression. Treatment of the gastric cancer cells with TSA activates the DLC-1 promoter activity through Sp1 sites located at -219 and -174 relative to the trans ...[more]