Ontology highlight
ABSTRACT:
SUBMITTER: Wilson AJ
PROVIDER: S-EPMC2939837 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Wilson Andrew J AJ Chueh Anderly C AC Tögel Lars L Corner Georgia A GA Ahmed Naseem N Goel Sanjay S Byun Do-Sun DS Nasser Shannon S Houston Michele A MA Jhawer Minaxi M Smartt Helena J M HJ Murray Lucas B LB Nicholas Courtney C Heerdt Barbara G BG Arango Diego D Augenlicht Leonard H LH Mariadason John M JM
Cancer research 20100112 2
Histone deacetylase inhibitors (HDACi) induce growth arrest and apoptosis in colon cancer cells and are being considered for colon cancer therapy. The underlying mechanism of action of these effects is poorly defined with both transcription-dependent and -independent mechanisms implicated. We screened a panel of 30 colon cancer cell lines for sensitivity to HDACi-induced apoptosis and correlated the differences with gene expression patterns induced by HDACi in the five most sensitive and resista ...[more]