Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC2679435 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Zhang Heng H Liu Chen-Ying CY Zha Zheng-Yu ZY Zhao Bin B Yao Jun J Zhao Shimin S Xiong Yue Y Lei Qun-Ying QY Guan Kun-Liang KL
The Journal of biological chemistry 20090326 20
The TAZ transcription co-activator has been shown to promote cell proliferation and to induce epithelial-mesenchymal transition. Recently we have demonstrated that TAZ is phosphorylated and inhibited by the Hippo tumor suppressor pathway, which is altered in human cancer. The mechanism of TAZ-mediated transcription is unclear. We demonstrate here that TEAD is a key downstream transcription factor mediating the function of TAZ. Disruption of TEAD-TAZ binding or silencing of TEAD expression blocke ...[more]