Ontology highlight
ABSTRACT:
SUBMITTER: Cuevas EP
PROVIDER: S-EPMC3925316 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Cuevas Eva P EP Moreno-Bueno Gema G Canesin Giacomo G Santos Vanesa V Portillo Francisco F Cano Amparo A
Biology open 20140215 2
Lysyl-oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family that catalyzes the cross-linking of collagens or elastins in the extracellular matrix, thus regulating the tensile strength of tissues. However, many reports have suggested different intracellular roles for LOXL2, including the ability to regulate gene transcription and tumor progression. We previously reported that LOXL2 mediates epithelial-to-mesenchymal transition (EMT) by Snail1-dependent and independent mechanisms, related ...[more]