Ontology highlight
ABSTRACT:
SUBMITTER: Zemlin M
PROVIDER: S-EPMC2680007 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Zemlin Michael M Schelonka Robert L RL Ippolito Gregory C GC Zemlin Cosima C Zhuang Yingxin Y Gartland G Larry GL Nitschke Lars L Pelkonen Jukka J Rajewsky Klaus K Schroeder Harry W HW
Journal of immunology (Baltimore, Md. : 1950) 20081201 12
In jawed vertebrates most expressed Ig H chains use only one of six possible D(H) reading frames. Reading frame (RF)1, the preferred reading frame, tends to encode tyrosine and glycine, whereas the other five RFs tend to be enriched for either hydrophobic or charged amino acids. Mechanisms proposed to favor use of RF1 include a preference for deletion over inversion that discourages use of inverted RF1, RF2, and RF3; sequence homology between the 5' terminus of the J(H) and the 3' terminus of th ...[more]