Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging.
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ABSTRACT:
SUBMITTER: Jackson TC
PROVIDER: S-EPMC2680608 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
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Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging.
Jackson T C TC Rani A A Kumar A A Foster T C TC
Cell death and differentiation 20081128 3
Distinct neuronal populations differ by the degree of damage caused from cellular stress. Hippocampal neurons of area CA1 are especially vulnerable to several stressors that increase as age advances. We show here that survival signaling, as measured by activated protein kinase B (AKT), was significantly reduced in the nuclear CA1 region across the lifespan compared with CA3. In agreement with these findings, the pro-apoptotic protein and AKT nuclear substrate, forkhead box O3a transcription fact ...[more]
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