Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA1.
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ABSTRACT:
SUBMITTER: Planche V
PROVIDER: S-EPMC6866595 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA1.
Planche Vincent V Koubiyr Ismail I Romero José E JE Manjon José V JV Coupé Pierrick P Deloire Mathilde M Dousset Vincent V Brochet Bruno B Ruet Aurélie A Tourdias Thomas T
Human brain mapping 20180113 4
<h4>Background</h4>Whether hippocampal subfields are differentially vulnerable at the earliest stages of multiple sclerosis (MS) and how this impacts memory performance is a current topic of debate.<h4>Method</h4>We prospectively included 56 persons with clinically isolated syndrome (CIS) suggestive of MS in a 1-year longitudinal study, together with 55 matched healthy controls at baseline. Participants were tested for memory performance and scanned with 3 T MRI to assess the volume of 5 distinc ...[more]
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