Ontology highlight
ABSTRACT:
SUBMITTER: Bose D
PROVIDER: S-EPMC2680985 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Bose Daniel D Pape Tillmann T Burrows Patricia C PC Rappas Mathieu M Wigneshweraraj Siva R SR Buck Martin M Zhang Xiaodong X
Molecular cell 20081101 3
Transcription initiation involves the conversion from closed promoter complexes, comprising RNA polymerase (RNAP) and double-stranded promoter DNA, to open complexes, in which the enzyme is able to access the DNA template in a single-stranded form. The complex between bacterial RNAP and its major variant sigma factor sigma(54) remains as a closed complex until ATP hydrolysis-dependent remodeling by activator proteins occurs. This remodeling facilitates DNA melting and allows the transition to th ...[more]