Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez-Martinez JM
PROVIDER: S-EPMC2681535 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20090302 5
The characterization of AmpC-type beta-lactamases was performed in a collection of 32 clinical Pseudomonas aeruginosa isolates with intermediate susceptibility or resistance to imipenem and ceftazidime. Twenty-one out of those 32 isolates overexpressed AmpC beta-lactamase, and the MICs of ceftazidime and imipenem were reduced after cloxacillin addition. Cloning and sequencing identified 10 AmpC beta-lactamase variants. Reduced susceptibility to imipenem, ceftazidime, and cefepime was observed on ...[more]