Ontology highlight
ABSTRACT:
SUBMITTER: Pohl K
PROVIDER: S-EPMC2681790 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Pohl Konstanze K Francois Patrice P Stenz Ludwig L Schlink Frank F Geiger Tobias T Herbert Silvia S Goerke Christiane C Schrenzel Jacques J Wolz Christiane C
Journal of bacteriology 20090227 9
The repressor CodY is reported to inhibit metabolic genes mainly involved in nitrogen metabolism. We analyzed codY mutants from three unrelated Staphylococcus aureus strains (Newman, UAMS-1, and RN1HG). The mutants grew more slowly than their parent strains in a chemically defined medium. However, only codY mutants were able to grow in medium lacking threonine. An excess of isoleucine resulted in growth inhibition in the wild type but not in the codY mutants, indicating that isoleucine plays a r ...[more]